TCR001-201 Phase I/II Study of Autologous T Cells Engineered Using the Sleeping Beauty System to Express T-Cell Receptors (TCRs) Reactive Against Cancer-specific Mutations in Subjects with Solid Tumors
Purpose of Study:To evaluate the objective response rate (ORR) (RECIST and iRECIST criteria) of subjects with solid cancers who receive TCR-T cell drug product, define the incidence of dose limiting toxicity (DLT) and the maximum tolerated dose (MTD) of T-Cell Receptor T cells, and evaluate the feasibility of TCR-T cell drug product manufacturing.
January 1, 2022 - January 1, 2025
MD Anderson Cancer Center
Email: [email protected]