Dr. William Vandivier is a Professor of Medicine, Director of the COPD Clinic, and a clinician-scientist trained in critical care medicine at the National Institutes of Health and in pulmonary medicine at the University of Colorado. He has broad experience performing basic, translational and clinical investigations, giving him the tools necessary to recruit patients for the proposed project. Since its inception, the core mission of the COPD Clinic at University of Colorado has been to advance the health and well being of COPD patients by delivering outstanding clinical care and offering patients the opportunity to participate in basic, translational and clinical research that has the potential to lead to novel therapies. Since 2005, the COPD Clinic has enrolled over 2,000 COPD patients in 18 investigator-initiated studies that range from mechanistic laboratory-based studies, to phase II clinical trials with biologic outcomes, phase III multicenter clinical trials with the NIH-funded COPD Clinical Research Network, and clinical effectiveness studies of proactive integrated care. The COPD Program has been highly successful with these research endeavors in part through the ability to partner with National Jewish Health, the Denver VA Medical Center and Kaiser Permanente. We have also established an Asthma Clinic and research program under the leadership of Fernando Holguin, MD. The Asthma Program also enrolls patients into multi-center clinical trials, NIH-funded phase II studies, and is now enrolling for the NIH-sponsored PrecISE Study. Dr. Vandivier and Dr. Holguin do not foresee any problems enrolling COPD and asthma patients for ACRC NETWORK studies.