There are several Airways Clinical Research Centers (ACRC) clinical trials currently in progress and at various stages of completion across the United States. If you live with COPD or asthma, or care for someone who does, see what trials are available close to your home.

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Trials Currently Recruiting Participants:

The ACRC network is studying whether having regular video calls with a pharmacist using a smart phone or computer will help adolescents and young adults with asthma to regularly take their prescribed inhaled medications and have fewer asthma symptoms.

Currently in the recruiting phase.

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Trials In Analysis Phase

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Though some medicines can help relieve symptoms of COPD, no treatment other than quitting smoking has been shown to slow the progression of the disease.

Losartan is a drug that may be useful in slowing the progression of COPD. This medication is currently used to treat high blood pressure and heart failure, and data from clinical trials suggest that it may be useful in slowing the progression of COPD, particularly emphysema. Losartan has not been approved to treat COPD. The purpose of this study was to see if losartan helps to slow the progression of COPD-related emphysema in the lungs.

The primary outcome of LEEP was to perform a placebo controlled trial of losartan for people with mild to severe COPD in ALA-ACRC centers to determine if it changes the rate of progression of emphysema, as measured by quantitative changes in high-resolution computed tomography (HRCT) of the lungs.

Follow-up on all participants was completed in 2021. Investigators are currently preparing a manuscript describing the results of the trial. We will share the results of the trial once they have been published.

Some LEEP participants have participated in an ancillary study to LEEP aimed at understanding the impact of the COVID-19 pandemic on people with COPD. Preliminary results of the study were presented at the American Thoracic Society conference in April 2021 (LaBedz, S. (2021, May 14-19). Anxiety, depressive symptoms, and attitudes about COVID-19 in patients with chronic obstructive pulmonary disease [Conference presentation]. ATS 2021 Conference, online). A manuscript will be submitted with complete results from Phase 1 of the study. An important finding from that study is the resilience of participants while coping with the restrictions and stress caused by the pandemic.

Co-funded by the National Heart, Lung and Blood Institute

Co-funded by the National Heart, Lung and Blood Institute

Do mobile and internet technology make clinical trials more convenient and cost effective?

Funded by the American Lung Association

Examines the relationship between anxiety, health status and prognosis, to inform appropriate treatment strategies.

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Funded by the American Lung Association

Evaluates measurements of cough symptoms and the impact of cough on quality of life for people with chronic cough.

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Funded by the American Lung Association

ZICO will look at how well tolerated and how safe taking zinc to treat chronic cough is. Results of COCO and ZICO will be used to develop a full-scale trial to test treating chronic cough with zinc acetate.

Page last updated: November 15, 2021

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