Preventing Lung Cancer Stem Cells From Self-Renewing
A major hurdle in lung cancer treatment is reducing cancer stem cells that are responsible for cancer drug resistance, metastasis and recurrence. We will decipher the way in which lung cancer stem cells self-renew after drug treatment. We will be focusing on a cell signaling system called Notch signaling and its role in regulating the self-renewal of cancer stem cells. We hope to discover new methods of identifying lung cancer stem cells and new ways to diminish cancer stem cells by restricting their self-renewal.