Obesity is an important risk factor for the development of asthma. Obese patients often use more medications, suffer worse symptoms and have reduced asthma control than lean patients. Poor asthma control over time can lead to airway remodeling, a feature of asthma that leads to diminished lung function. We would like to gain a greater understanding of the molecular and cellular mechanisms governing airway remodeling in obese people with asthma. We will investigate how these mechanisms contribute to the lack of responsiveness to medications in obese asthma. Our goal is to identify potential therapeutic targets for treatment of airway remodeling in obese people with asthma.