Measuring indirect transmission-reducing effects in tuberculosis vaccine efficacy trials: why and how?

This opinion paper emphasizes the importance of measuring the effects of tuberculosis (TB) vaccines in both vaccinated and unvaccinated individuals. By understanding how these vaccines directly protect individuals and indirectly reduce transmission, policymakers can make informed decisions about introducing these vaccines into immunization programs to fight against TB. First author Kristin Nelson, PhD, MPH was awarded the Lung Association Catalyst Award for her work in TB vaccines.