Hypoxia‐induced pulmonary hypertension upregulates eNOS and TGF‐β contributing to sex‐linked differences in BMPR2+/R899X mutant mice

This animal study found a new mechanism that may explain some of the sex differences in pulmonary arterial hypertension (PAH), or high blood pressure in the lungs. This is important because PAH is three times more prevalent in females, but males have a worse prognosis, so future treatments must be customized for sex. Senior author Suellen Oliveria, PhD, was funded by the Lung Association Catalyst Award for her work in pulmonary arterial hypertension.
Clinical Trials: Why It's Important to Participate
, | Dec 14, 2023