Navneet Dhillon, PhD
University of Kansas Medical Center Research Institute, Inc.
Research Project:
Distinguishing Long COVID-19 Patients Through Proteins of Circulating Extracellular Vesicles
Grant Awarded:
- Emerging Respiratory Pathogen Award
Research Topics:
- basic biologic mechanisms
- biomarkers
- clinical research
- pathology
Research Diseases:
- COVID-19
- respiratory viruses
The COVID-19 pandemic has been associated with an abnormally functioning immune system response and blood vessel injury. These factors may cause patients to experience lung and heart issues. Some people continue to experience health problems long after having COVID-19, a condition known as post-COVID-19 syndrome or long COVID-19. While the symptoms of long COVID-19 can vary widely, lung-related symptoms are common, including shortness of breath, chest pain and persistent cough. Extracellular vesicles (EVs) are tiny, membrane-bound particles released from various cells that may act as communicators between cells and organs. Studies have demonstrated that the increased presence of EVs in blood in response to SARS-CoV-2 infection and specific indicators associated with these EVs may be used to identify the severity of COVID-19 illness. We will examine whether patients with long-term COVID-19 might be distinguished from fully recovered individuals based on the extra pro-inflammatory and tissue-remodeling proteins of circulating tiny EVs and whether this is related to the development of chronic respiratory problems after COVID-19 disease.
Page last updated: October 7, 2024
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