This website uses cookies. By continuing you are agreeing to our privacy policy.

Mohamed Abazeed, M.D., Ph.D.

Headshot of Abazeed
Cleveland Clinic Foundation
Mapping and Exploiting the Subclonal Architecture of Lung Adenocarcinoma
Lung Cancer Discovery Award
Funded by LUNG FORCE

While recent large-scale sequencing studies of cancers have revealed their overall mutational landscapes, they have largely disregarded the individual genetic diversity that has been identified in most solid tumors, which has critical consequences for tailoring personalized cancer patient care. The distinct subclones that constitute this intra-tumoral diversity are dynamic in response to inherent genetic drift or selection related to anti-cancer treatments. Thus, the sampling of a tumor for genomic analyses in a fixed time and space offers only a restricted view of its genetic composition. For this reason, we have developed mathematical and experimental models to study the stratification of tumor subclones in topographic space and time. Upon completion, our work will provide a greater understanding of subclonal tumor dynamics and advance new strategies that seeks to exploit our understanding of clonal architecture to improve the care of patients with lung cancer.

Update: I am focused on studying recently discovered genomic alterations in order to better understand and therapeutically target cancers. This year, we studied the role of mutations in the BRAF gene and the mitogen-activated protein kinase (MEKI) in lung cancer. We showed that certain BRAF variants are more likely to survive radiation therapy. We also demonstrated that the efficacy of concurrent treatments using targeted therapies and radiation can vary based on the type of BRAF variant. Our results indicate that treatments that antagonize MEK1 can be potent therapeutic sensitizers in cells containing certain mutations in BRAF. This finding may lead to an effective treatment strategy in these tumors.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl
What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.