Mohamed Abazeed, M.D., Ph.D.
Cleveland Clinic Foundation
Funded by LUNG FORCE
Mapping and Exploiting the Subclonal Architecture of Lung Adenocarcinoma
While recent large-scale sequencing studies of cancers have revealed their overall mutational landscapes, they have largely disregarded the individual genetic diversity that has been identified in most solid tumors, which has critical consequences for tailoring personalized cancer patient care. The distinct subclones that constitute this intra-tumoral diversity are dynamic in response to inherent genetic drift or selection related to anti-cancer treatments. Thus the sampling of a tumor for genomic analyses in a fixed time and space offers only a restricted view of its genetic composition. For this reason, we have developed mathematical and experimental models to study the stratification of tumor subclones in topographic space and time. Upon completion, our work will provide a greater understanding of subclonal tumor dynamics and advance new strategies that seeks to exploit our understanding of clonal architecture to improve the care of patients with lung cancer.
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