Treating and Preventing Histoplasmosis

How Histoplasmosis Is Treated

Most cases of histoplasmosis go away on their own in a few weeks without treatment. However, for severe, chronic or disseminated histoplasmosis, antifungal medication is recommended. The amount of time you have to receive treatment will depend on the severity of the infection and your immune status. Normally the course of treatment ranges from three months to a year.

Preventing Histoplasmosis

For most people, there are no long-term consequences of histoplasmosis. Recurrence is possible, however, especially if you have a weakened immune system. So, it is important to take precautions to avoid infection in the future. This includes avoiding activities or jobs that lead to high levels of exposure to the fungus. Steps that can be taken to reduce the risk of exposure include:

  • Physically remove the hazard
  • Replace the hazard with a safer option
  • Isolate yourself from exposure
  • Change the way you work to decrease exposure
  • Use personal protective equipment (PPE) if you must work with the hazard.

Finding Support

To talk to a trained respiratory professional who can help answer your questions and connect you with additional support, call the Lung Association's Lung HelpLine at 1-800-LUNGUSA. For more severe or chronic forms of histoplasmosis, join an in-person or virtual support group through the Better Breathers Clubs, become a member of the Patient & Caregiver Network which is an online support program through the American Lung Association,, and connect with others on our Living with Lung Disease Support Community page.

Learn More

Reviewed and approved by the American Lung Association Scientific and Medical Editorial Review Panel.

Page last updated: June 7, 2024

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