Yanzhuang Wang, PhD

Research Project:
SARS-CoV-2 Modulates the Golgi Structure to Facilitate Viral Trafficking

Grant Awarded:

COVID-19 Respiratory Virus Research Award

Research Topics:

basic biologic mechanisms
gene expression transcription
proteomics

Research Diseases:

COVID-19
respiratory viruses

Infection with SARS-CoV-2, the virus that causes COVID-19, relies on a structure found in cells called the Golgi apparatus for viral particle assembly and transport in the host cell. The Golgi is a membrane-bound structure that serves as a transport center of the cell by distributing proteins to their proper locations. To perform these important functions, the Golgi needs to form a multilayer, pancake-like, stacked membrane structure. SARS-CoV-2 infection causes fragmentation of the Golgi structure, scattering it throughout the cell. The goal of this collaborative project by Dr. Wang (a Golgi expert) and Dr. Andrew Tai (a physician scientist with expertise in RNA viruses) is to investigate exactly how SARS-CoV-2 infection alters the Golgi structure and how Golgi structural changes affect SARS-CoV-2 virus intracellular transport and release. We expect that this research may identify novel therapeutic targets that can be used in the treatment of SARS-CoV-2 infection.

Page last updated: October 3, 2023

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