The COVID-19 and Immunocompromised Connection

People Who Are Immunocompromised Are At Higher-Risk for Severe COVID-19

People who are moderately and severely immunocompromised are more likely to become severely ill with COVID-19. They may not be protected even if they are up to date on their COVID-19 vaccines and may need to take additional precautions to stay safe.

What does it mean to be immunocompromised? The immune system defenses are lowered and may not be able to fight off infections and diseases. This can be due to a medical condition or treatment for a medical condition.

Immunocompromising health conditions:

  • Autoimmune diseases include lupus, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease
  • Certain cancers, especially cancers of the blood
  • HIV infection
  • Primary Immunodeficiency including DiGeorge syndrome, Wiskott-Aldrich syndrome, Bruton’s agammaglobulinemia
  • Certain developmental disabilities can put you at increased risk of developing immunocompromising conditions.

Immunosuppressants are medications that serve a variety of roles involving the immune system and may reduce or suppress your immune system response. They differ depending on what they are being prescribed for.

Different categories of immunosuppressants include:

  • Biologics such as certain treatments for eosinophilic asthma.
  • Calcineurin inhibitors used to manage autoimmune conditions including interstitial lung disease (ILD).
  • Corticosteroids such as prednisone, used in some anti-inflammatory medications. 
  • Monoclonal antibodies used as part of cancer treatment.
  • Inosine monophosphate dehydrogenase (IMDH) inhibitors and rapamycin inhibitors are used to help prevent organ transplant rejection.
  • Janus kinase (JAK) inhibitors are used as treatments for certain autoimmune diseases.

Health conditions that may be treated with immunosuppressants include:

  • Some people with asthma, COPD, sarcoidosis or pulmonary fibrosis.
  • People going through cancer treatment.
  • People who get organ transplants to help prevent organ rejection.
  • People with autoimmune diseases such as lupus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease.
  • People who get stem cell transplants, this can include people who have blood cancers, blood disorders and bone marrow disorders.

Precautions people who are immunocompromised can take to help protect themselves from COVID-19

1. Stay up to date with recommended COVID-19 vaccines. The immune response from vaccination in moderately to severely immunocompromised people may be lower than people who are not immunocompromised. There are different vaccinations recommendations for this group.

You can read more about the dosing schedule for people who are moderately to severely immunocompromised on the CDC website.

2. Consider wearing a well-fitting, high quality mask.

Mask Types


  • Multiple layers of breathable fabric
  • Wash daily
  • Some protection


  • Multiple layers of non-woven fabric
  • One-time use
  • More protection


  • Filtration is different depending on standards
  • Limited reuse
  • More protection


  • NIOSH approved
  • Limited reuse
  • Highest protection

3. Check COVID-19 community levels in your area to help determine individual preventive strategies.

4. Open windows and increase ventilation throughout indoor spaces. Improving ventilation can help reduce virus particles in the home. CDC has an interactive ventilation tool to learn how you can decrease COVID-19 virus particles during and after guest visits.

5. Avoid crowded indoor spaces

6. Order free at-home tests  to have on hand when you need them. If you need more tests, you can check with your health insurance plan too. The CDC has a locator  to find no-cost COVID-19 testing locations near you. .

Build Your Personal COVID-19 Plan

A COVID-19 plan will allow you to be prepared in case you get sick with COVID-19.

To download and complete your plan, learn more

Visit our preventing COVID-19 page for more tips.

Learn More

Steps friends, family and community members can take to help protect immunocompromised people from COVID-19:

  1. Stay up to date on recommended COVID-19 vaccines.
  2. Get tested if you have symptoms or before contact when community levels are medium or high.
  3. Consider wearing a mask when indoors.
  4. Check the COVID-19 community levels to determine additional preventive strategies.

Page last updated: February 16, 2023

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