Research Project: Role of Ketogenic Diet in KRAS-mutant Lung Tumor
Lung Cancer Discovery Award
basic biologic mechanisms
combination therapies experimental therapeutics
Ketogenic diet has been proposed as a novel, nontoxic, cost-effective adjuvant therapy in combination with chemotherapy and radiation therapy in the treatment of cancer. However, the role of ketogenic dietary interventions in cancer treatment remains controversial due to insufficient preclinical mouse studies and imperfect clinical trial designs. In preclinical mouse models, our preliminary studies of different subgroups of non-small cell lung cancer with mutations in the KRAS gene exhibit differential responses to a ketogenic diet in tumor growth. We will further elucidate the underlying mechanisms and determine whether the ketogenic diet can serve as an adjuvant to cancer therapy in the treatment of KRAS-mutant non-small cell lung cancer, a type of lung cancer with the lowest survival, worse prognosis and poor response rates to standard cancer treatments.