Research Project: Immunological Imprinting and Cross-reactive Immune Responses in COVID19
COVID-19 Respiratory Virus Research Award
SARS-CoV-2 is a betacoronavirus that belongs to a large family of viruses capable of infecting both mammals and birds. Some of these viruses include the coronaviruses responsible for the common cold in humans. We have shown in the past that prior exposure to these common cold coronaviruses may result in the generation of cross-reactive immune responses upon SARS-CoV-2 infection. However, the impact of pre-existing immunity and cross-reactivity immune responses to other coronaviruses in SARS-CoV-2 is not totally clear. We will study how cross-reactive immune responses against multiple coronaviruses can impact SARS-CoV-2 immune responses. In a second step, we will use this information to identify and generate monoclonal antibodies with the ability to exhibit protection against multiple coronaviruses. Our research will help to develop human therapeutics against coronaviruses that can have pathogenic potential.