Research Project: Role of Fungal Translocation in Modulating Post-acute Sequelae of COVID-19
COVID-19 Respiratory Virus Research Award
basic biologic mechanisms
SARS-CoV-2 infection can cause translocation (leakiness) of bacteria and fungi from the lungs or gut to the blood. This translocation can result in systemic inflammation, dysregulated metabolic processes, and worsen the severity of the disease. This study aims to understand the role of microbial translocation in sustaining inflammation after recovering from acute COVID-19. Our hypothesis is that the infection leads to leakiness in the lungs or gut, which can contribute to long-term COVID-19 by influencing inflammatory and metabolic processes. Understanding how microbial translocation contributes to potential long-term complications will establish the foundation for developing innovative biomarkers and therapeutic interventions for Long COVID, or post-acute sequelae SARS-CoV-2 infection (PASC).