Research Project: Promoting Natural Killer Cell-driven Immunity Against Lung Cancer
Lung Cancer Discovery Award
combination therapies experimental therapeutics
The immune system plays a pivotal role in the elimination of tumor cells and it can be harnessed for the development of immunotherapies. However, many patients with lung cancer are either resistant or develop acquired resistance to the current immunotherapies available. We are developing an alternative approach that has unique mechanism of action: it retains a key receptor on the surface of white blood cells for subsequent recognition and destruction of tumor cells. Our molecule is an antibody that works in conjunction with a standard antibody that is used for marking malignant cells. We propose to test these antibodies in combination in lung cancer models. In the short term, our studies will generate new information about how they harness the immune system to inhibit lung cancer. In the long term, our studies will help provide a new treatment for patients and could prolong their lives or even cure this disease.