Research Project: Cysteinyl Leukotriene Feedforward Signaling Between Mast Cells and Platelets in Allergic Inflammation
basic biologic mechanisms
Platelets can play major roles in inflammatory responses, particularly in inflammation that underlies prevalent respiratory diseases such as asthma. Mast cells are a type of white blood cell that play a major role in inflammatory responses, but little is understood about the potential role of platelets in the regulation of mast cell function. In this study, we will investigate whether platelets directly promote mast cell activation, what the mechanisms are that underlie this process, and how this process promotes lung allergic information. Our findings will help develop new therapeutic strategies that target this process and validate useful allergic/inflammatory diagnostic biomarkers.