Hasina Outtz-Reed, MD, PhD

Research Project:
Lymphatic Endothelial Cell Crosstalk in Tertiary Lymphoid Organ Formation and Lung Injury

Grant Awarded:

Innovation Award

Research Topics:

basic biologic mechanisms
immunology immunotherapy
pathology

Research Diseases:

COPD
emphysema
pulmonary vascular disease

Chronic obstructive pulmonary disease (COPD) affects over 14 million individuals in the U.S and is the fourth leading cause of death. Cigarette smoke is the most common cause of this disease. However, underlying factors that determine why some individuals develop progressive COPD while others do not is not fully understood. The lung lymphatic vessels are a completely separate drainage system from blood vessels but play an important role in lung function. We have previously found that the lymphatic vessels are damaged in COPD, using both human tissue and animal models of this disease. We will determine the mechanisms by which the lung lymphatics affect the development of COPD after cigarette smoke exposure through interactions with the immune system.

Page last updated: October 9, 2023

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