Andrea Kasinski, PhD

Research Project:
Active Loading of Extracellular Vesicles Depletes Tumors of miRNAs

Grant Awarded:

Innovation Award

Research Topics:

basic biologic mechanisms
gene expression transcription

Research Disease:

lung cancer

While various mechanisms contribute to lung cancer, loss of a type of tumor-suppressing molecules called microRNAs is one that specifically gives lung cancer cells a competitive advantage. Based on this knowledge, which was uncovered over two decades ago, approaches to understand the mechanisms that drive global microRNA loss have been under intense investigation. We recently identified a mechanism that can explain this loss. We will validate this mechanism, which we hypothesize lung cancer cells use to rid themselves of large subsets of microRNAs. If supported, we will answer a question that has been plaguing the lung cancer field for decades–how do lung cancer cells rid themselves of a major cohort of tumor-suppressive microRNAs? And, through identifying the mechanism, we will be poised to evaluate interventions that could prevent microRNA loss, leading to demise of the cancer.

Page last updated: December 4, 2023

Join the Patient & Caregiver Network

End Youth Vaping

10 Tips to Protect Yourself from Unhealthy Air

State of the Air Key Findings

Become an Advocate

Events Near You

Andrea Kasinski, PhD

A Breath of Fresh Air in Your Inbox

Thank You!

Make a Donation

Become a Lung Health Insider

Select Your Location

Change Language

Lung HelpLine

1-800-LUNG-USA