Wei Tao, PhD

Wei Tao, PhD

Brigham and Women's Hospital, Inc.

Research Project:
Inhalation Delivery of mRNA via Targeted NPs for Lung Cancer Treatment

Grant Awarded:

  • Lung Cancer Discovery Award

Research Topics:

  • combination therapies experimental therapeutics
  • gene expression transcription
  • gene therapy

Research Disease:

  • lung cancer

Funded by the Courtney Cox Cole Lung Cancer Research Award

The vast majority of lung cancers fall into the category called non-small cell lung cancer (NSCLC). However, the current therapies still suffer from poor outcomes and side effects. We propose a new type of therapy, called mRNA-mediated therapy, to solve these challenges. mRNA is a type of biomolecule that can be translated to functional proteins in cells and exert its corresponding functions, such as making tumor cells die and therefore shrink tumors. To achieve this goal, we will design a new type of tiny particles, called targeted nanoparticles, which can carry and deliver anti-tumor mRNA molecules to lung tumor cells in a targeting manner. We will use a delivery technique, called inhalation, to assist these mRNA-carried particles efficiently arriving in mouse lung tumor cells through the airway. We expect this new therapeutic strategy can not only improve the treatment efficacy and lower side effects for lung tumors but also might pave the way for the development of other inhaled mRNA medicine or vaccines. 

Page last updated: October 16, 2023

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