The Regents of the University of California, San Diego
Research Project: Metabolomics Determinants of Post-Acute Sequelae of COVID-19
COVID-19 Respiratory Virus Research Award
The fast spread of COVID-19 infection throughout populations across the globe has led to an increasing variety of symptoms. Some of these include prolongation of COVID-19 infection symptoms, also known as post-acute sequela of COVID-19 (PASC), or long haul COVID-19. PASC has a considerable negative influence on both a person's quality of life and their ability to return to work. Studies have reported that females are more likely to develop PASC than males following acute infection. It has not yet been determined if the Omicron variant, which is now the most common, contributes to PASC and if it does, to what extent. We want to analyze the metabolic signature (chemical makeup) of PASC in relation to the many COVID-19 variants in an effort to identify biomarkers that have the potential to be used in diagnostics and therapy. To do this, we will employ a method called unbiased metabolomics. We will identify metabolic signatures for risk of developing PASC in relation to different variants and in relation to sex.