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Bina Choi, MD
Brigham and Women's Hospital, Inc.
Research Project:
Proteomics Signatures of Quantitative Interstitial Abnormalities and Impaired Respiratory Health
Grant Awarded:
- ACRC Early Career Investigator
Research Topics:
- biomarkers
- clinical research
- computational biology
- imaging radiology
- proteomics
Research Diseases:
- COPD
- emphysema
- interstitial lung disease
- pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are smoking-related progressive lung diseases with poor outcomes, and patients with these diseases have permanent damage to their lungs in the form of scarring (fibrosis) as well as airspace dilatation and destruction (emphysema), respectively. Since current treatments slow future progression but do not reverse disease, there is an important need to identify and characterize the precursors to IPF and COPD. This proposal focuses on one precursor, called quantitative interstitial abnormalities (QIA). This study aims to use protein-based blood biomarkers to better characterize QIA and identify people with QIA at highest risk for QIA progression to fibrosis or emphysema and progression to death.
Page last updated: October 9, 2023
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