Losartan Effects on Emphysema Progression (LEEP) Trial

Clinical Trials

Institution: Nationwide

Type: Multi-Center Trial

Purpose: The American Lung Association sponsors studies of treatments for COPD to help find ways to make people’s lives better. Right now the Lung Association is sponsoring a clinical study of a possible treatment for COPD with emphysema. The drug being tested is Losartan. Losartan is a drug commonly used to treat high blood pressure. Results from early studies suggest that Losartan may actually slow damage to the lungs caused by emphysema related to COPD.

Dates: May 1, 2015 - December 31, 2019

Disease: COPD

About the study:

More research needs to be done to understand the effect Losartan may have on the lungs. As a next step, the American Lung Association network of Airways Clinical Research Centers (ACRC) are conducting a multicenter randomized trial. This study will compare Losartan versus a placebo in people with emphysema. The study will use high resolution CT scans (HRCT) to see if Losartan slows the progression of emphysema.

Has Losartan been recalled by the FDA because of contamination?

Yes, several batches of losartan (and similar drugs) have been recalled because of contamination with a suspected carcinogen, one or more nitrosamine compounds. Elevated levels of nitrosamines are associated with an increased risk of cancer. The losartan used for this trial has not been recalled. The losartan used for the trial has been tested and meets FDA safety standards for nitrosamines.

How does the study work?

People who are eligible for the study and agree to join, will be randomly assigned to receive Losartan or placebo for one year. Patients will receive HRCTs at the beginning and end of the study.

Who is eligible to enroll in the study?

We are looking for adults 40 years of age or older with COPD to join our study. The Losartan Effect on Emphysema Progression(LEEP) trial is being conducted at ACRC centers around the country. A list of centers is provided below. People who enroll will need to go to the study site every three months for one year.

Does it cost anything to enroll?

It is free to enroll in this study. Supplies of Losartan will be provided by the study free of charge. Study participants will receive payments for their time and expenses, and there will be no charges for study visits or clinical examinations.

The study is sponsored by the American Lung Association and the National Heart Lung and Blood Institute (NHLBI). If you are interested in learning more about joining this important study, please contact the center closest to you.

Below is a list of recruiting centers.

Register by Contacting a LEEP Center Near You: LEEP is currently recruiting research participants. If you do not see a location near you, please check back often as new locations will be added soon.


University of Alabama at Birmingham Lung Health Center
526 20th Street South
Birmingham, AL 35249
Contact: Necole Harris, Lead Coordinator
(205) 934-9240
[email protected]


Asthma and Airways Disease Research Center
University of Arizona
1501 North Campbell Avenue
Room 2344
Tucson, AZ 85724
PO Box 245030
Contact: Sarah E. David, MPH, Lead Coordinator
(520) 626-4200
[email protected]


University of California—San Francisco Airway Clinical Research Center
University of California, San Francisco
505 Parnassus Avenue
Room 1331
San Francisco, CA 94105
Contact: Julian Silva, MA, CCRP, Senior Clinical Research Coordinator
(415) 476-5418
[email protected]

University of California at San Diego Airway Research & Clinical Trials Center
University of California, San Diego
210 Dickinson Street
CTF-A/Room 102
San Diego, California 92103
Contact: Amber Martineau, Lead Coordinator
(619) 471-0817
[email protected]


National Jewish Health
1400 Jackson Street
Room K-239
Denver, CO 80206
Contact: Juno Pak, Lead Coordinator
(303) 398-1443
[email protected]


University of South Florida
653 West 8th Street
Faculty Clinic, 3rd Floor
Jacksonville, FL 32209
Contact: Catherine Renee Smith, Lead Coordinator
(813) 631-4024
[email protected]

University of Florida in Jacksonville 
University of South Florida Asthma, Allergy and Immunology
Clinical Research Unit
13801 Bruce B. Downs Blvd., Suite 505
Tampa, FL 33613
Contact: Fallon Wainwright, BS, Lead Coordinator
(904) 244-1106
[email protected]


Northwestern University
676 North Saint Clair
Chicago, IL 60611
Contact: Jenny Hixon, BS, CCRC, Lead Coordinator
(312) 926-0975
[email protected]

University of Chicago Hospitals
University of Chicago
5841 South Maryland Avenue
MC 6076
Chicago, IL 60637
Contact: Virginia Zagaja, Lead Coordinator
(773) 702-4012
[email protected]

University of Illinois at Chicago
University of Illinois – Breathe Chicago Center
1220 South Wood Street
3rd Floor, MC 619
Chicago, IL 60608
Contact: Lourdes Norwick, Research Nurser
(855) 494-3393
[email protected]

Rush University Medical Center
Allergy and Asthma Immunology Clinic
Rush Presbyterian Hospital
1725 West Harrison Street
Suite 306
Chicago, IL 60612
James Moy, (312) 942-5987 or [email protected]
Ben Xu, (312) 942-5987 or [email protected]


St. Vincent Airways Clinical Research Center
8333 Naab Road
Suite 301
Indianapolis, IN 46260
Contact: Ellen Looney, BS, Lead Coordinator
(317) 338-8030
[email protected]


University of Michigan
1500 East Medical Center Drive
Ann Arbor, MI 48109
Contact: Cheryl Majors, Lead Coordinator
(734) 764-7388
[email protected]


Washington University School of Medicine
Division of Pulmonary and Critical Care Medicine
660 S. Euclid Avenue
Campus Box 8052
St. Louis, Missouri 63110
Contact: Jaime J. Tarsi, RN, MPH, Lead Coordinator
(314) 747-3074
[email protected]

New York

Columbia University
Columbia University Medical Center
622 West 168th Street
PH 8, Room 859
New York, NY 10032
Contact: Ann Privorotskiy, Clinical Research Coordinator
(212) 305-0251
[email protected]

Icahn School of Medicine
Mount Sinai National Jewish Health Respiratory Institute
One Gustave L. Levy Place
Box 1118
New York, New York 10029
Diana Valerio, BS/CCRC, Lead Coordinator
(212) 241-9538
[email protected]

Karol Perez, Lead Coordinator
(212) 241-6593
[email protected]

New York University School of Medicine
New York University
462 First Avenue NB 7N24
New York, NY 10016
Contact: Karen Carapetyan, MA, Lead Coordinator
(212) 263-2252
[email protected]

Weill Cornell Medicine
Division of Pulmonary and Critical Care Medicine
1305 York Avenue, 10th Floor
New York, NY 10021
Contact: Alicia Morris, Lead Coordinator
(646) 962-2741
[email protected]

North Carolina

Duke Asthma Allergy Airway Center
1821 Hillandale Road
Suite 25A
Durham, North Carolina 27705
Contact: Catherine Foss, BS, RRT, RPFT, CCRC, Lead Coordinator
(919) 479-0861
[email protected]


Temple University
Department of Thoracic Medicine and Surgery
3440 North Broad Street
Kresge Building, Suite 700
Philadelphia, PA 19140
Contact: Francine McGonagle, BSN, RN, CCRP, Lead Coordinator
(215) 707-1359
[email protected]

University of Pittsburgh Medical Center
3471 Fifth Avenue
Kaufmann Medical Building, Suite 1211
Pittsburgh, PA 15213
Contact: Elizabeth Stempkowski, Lead Coordinator
(412) 605-1904<
[email protected]


Baylor College of Medicine Medical Center
Baylor University
6620 Main Street
Suite 11B.16
Houston, TX 77030
Contact: Laura Bertrand, RN, RPFT, Lead Coordinator
(713) 798-2681
[email protected]


University of Vermont
Vermont Lung Center
792 College Parkway, Suite 305
Colchester, VT 05446
Contact: Erika Gonyaw
(802) 847-8839
[email protected]


Pacific Northwest Airways
VA Puget Sound HCS, HSR&D, s-152
1660 S. Columbian Way
Seattle, WA 98108
Contact: Ed Udris, Lead Coordinator
(206) 764-2558
[email protected]

Page last updated: April 13, 2020

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