Yuru Liu, Ph.D.

Yuru Liu, Ph.D.

Institution: University of Illinois at Chicago

Project: Bioactive lipid mediated Endothelial niche regulation in alveolar epithelial repair

Grant(s): Innovation Award

The alveoli are small, fragile air sacs located in clusters at the end of the bronchial tubes deep in the lungs. The alveolar barrier of the human lung is constantly exposed to bacteria, viruses and particles and is susceptible to inflammation and injury. Therefore, the proper repair of injured alveoli is essential, but the precise signals and mechanisms involved are not clear. We will define the role of a chemical messager called endothelial-derived mediator sphingosine-1-phosphate in driving alveoli repair. In the long term, this knowledge has the potential to facilitate the discovery of therapeutic targets to accelerate lung repair and prevent the chronic lung conditions resulting from improper recovery.

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