University of New Mexico
How Lack of CIS Molecule Leads to Allergic Lung Disease
Allergic asthma is a major health problem, but the causes are not well understood. Research has newly identi-fied a molecule called CIS that may be deficient in people with allergic lung disease. This research will explore the ways in which levels of this molecule are regulated in the body. Dr. Yang will study how CIS is regulated, what cellular signals are disrupted by CIS, how CIS controls the development of pro-allergic immune cells called T helper cells, and how CIS deficiency leads to allergic lung disease. The results will potentially provide novel insights into the development of allergic lung disease, and may suggest new therapeutic and preventive methods.