Weiwen Long, Ph.D.

Weiwen Long, Ph.D.

Institution: Wright State University

Project: Potential Therapeutic Target for Lung Adenocarcinoma with KRAS Mutations

Grant(s): Lung Cancer Discovery Award

Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancers. About 30% of LUADs have mutations on the KRAS gene. However, directly targeting the KRAS mutants with drugs has been challenging. Hence, there is an unmet need to identify new therapeutic targets for treating LUADs with KRAS mutants (LUAD-KRAS Mts). We will define the role of a protein called FBXL16 in promoting tumor development and progression of LUAD-KRAS Mts. Our ultimate goal is to define FBXL16 as a novel prognostic marker and/or a potential therapeutic target for treating this subtype of lung cancer. 

Freedom From Smoking Clinic
, | Oct 25, 2021
Lung Mind Alliance Convening
, | Dec 08, 2021