University of Pittsburgh
Determining How Two Genes Interact in Lung Cancer
Recent advances in the treatment of lung cancer have confirmed that the disease is not a single disease entity but rather a collection of distinct cancers driven by cancer genes called oncogenes which cause the tumors to grow. This knowledge has led to the development of targeted therapies for a percentage of patients. One im-portant oncogene, c-MET, is required for a tumor to grow while another gene, TWIST 1, has been shown to regulate the c-MET gene. This study will determine how these two genes interact and how drugs may modulate their activity.