University of California, San Diego
Seeking Better Understanding of Allergic Asthma
Many people with asthma have worsening airways inflammation after exposure to their allergy triggers. We have previously found that a white blood cell type in the lung, called type 2 innate lymphoid cells (ILC2), is critical to causing inflammation in the lung after exposure to the fungal allergen Alternaria. We have since identified that ILC2 function can be controlled by asthma-associated molecules called leukotrienes. We will be testing how leukotrienes control the function of ILC2 in animal models of asthma and identify novel ILC2 leukotriene receptor pathways. Our research could lead to the discovery of therapeutic targets for allergic asthma.