Seyed Javad M. Moghaddam, M.D.

Seyed Javad M. Moghaddam, M.D.

Institution: University of Texas M.D. Anderson Cancer Center

Project: Developing Immuno-Prevention and Treatment Modalities for KRAS Mutant Lung Cancer

Grant(s): Lung Cancer Discovery Award

Worldwide, lung cancer is the leading cause of cancer death. KRAS mutations are the most common gene mutations found in lung cancer, which are heavily associated with tobacco exposure, and have a poor prognosis. Unfortunately, unlike other types of lung cancer, our knowledge of the molecular mechanisms affecting KRAS induced lung cancer growth is substantially deficient. Moreover, attempts to use drugs to target KRAS mutant lung tumors have not been very successful, clearly indicating that alternative strategies are needed to bring clinical benefits to these patients. We seek to understand specific pathways that relay KRAS mutant lung cancer growth and its promotion by chronic inflammatory lung diseases. We aim to target these pathways and ultimately develop novel personalized preventive and therapeutic strategies for this fatal but common form of lung cancer. 

Freedom From Smoking Clinic
, | May 02, 2022
Freedom From Smoking Clinic
Virginia Beach, VA | May 10, 2022