Sarah Clark, Ph.D.

Sarah Clark, Ph.D.

Institution: University of Colorado

Project: Using Probiotics to Improve Pneumonia Treatment  

Grant(s): Innovation Award

Pneumonia is a leading infectious cause of death. A primary culprit of this disease is the bacterial pathogen Streptococcus pneumoniae. Current S. pneumoniae vaccines have limited efficacy against lung infections, and antibiotic resistance makes these infections extremely difficult to treat. To address this critical health issue, we will explore the potential for a novel probiotic-based approach to improve protection against S. pneumoniae. Probiotics are non-pathogenic, or commensal, bacteria with protective benefits. We will focus on a prevalent airway commensal that we found protects against S. pneumoniae lung infection in mice. This protective effect relies on activation of the immune system. Understanding how commensal bacteria improve protection against bacterial pathogens will allow us to explore the exciting potential for new probiotic bacteria from the respiratory tract and probiotic-derived immunotherapy for the treatment of pneumonia.

Freedom From Smoking Clinic
, | Oct 25, 2021
Lung Mind Alliance Convening
, | Dec 08, 2021