Nikhil Joshi, Ph.D.

Nikhil Joshi, Ph.D.

Institution: Yale University School of Medicine

Project: Investigating the function of tumor-specific T cells in non-small cell lung

Grant(s): Lung Cancer Discovery Award

Therapies targeting immune cells have revolutionized the treatment of lung cancer. These therapies work by driving immune cells called T cells to killing cancer cells, which leads to the elimination of the disease. Yet, immune-targeting therapies do not work in most patients. To understand why, scientists have been looking at T cells inside cancers from patients, trying to figure out how to fix them. Our research has shown that another source of T cells comes from the tumor draining lymph node, and that the T cells in the lymph node may be better targets for immune-targeting therapies. We will identify if lymph node T cells are present in lung cancer patients and tests drugs that could be used to improve immune targeting therapies in lung cancer patients.

Better Breathers Club | Atrium Health: Cabarrus
Concord, NC | Mar 26, 2020
Freedom From Smoking Clinic
Toledo, OH | Nov 02, 2020