Wayne State University
How Immune System Works Differently in Sarcoidosis
Sarcoidosis is an inflammatory disorder that can affect multiple organs throughout the body. Its course and outcome are difficult to predict in each individual patient. Normally, immune protein cells in the body are equipped to recognize invaders, triggering an inflammatory response in an attempt to kill the invading foreign pathogens. In healthy individuals, inflammation shuts down once an infection is fought off; however, this pro-cess remains sustained in sarcoidosis patients. Dr. Samavati and team will investigate why these immune proteins work differently and how the inflammatory process continues to be activated in sarcoidosis patients compared to healthy individuals. The findings may lead to more effective drug therapies.