Lingtao Jin, Ph.D.

Lingtao Jin, Ph.D.

Institution: University of Florida

Project: Targeting Protein to Overcome Immunotherapy Resistance in Small Cell Lung Cancer

Grant(s): Innovation Award

Small cell lung cancer accounts for around 15% of lung cancer cases and is the most aggressive subtype of lung cancer, with a five-year survival rate of less than 5%. The results of numerous clinical trials have been disappointing and to date no approved targeted therapy for small cell lung cancer is available. As a result, treatment options for small cell lung cancer have not had the same progress as non-small cell lung cancer.  Immunotherapy that boosts the immune system to eliminate cancer cells has demonstrated unprecedented clinical activity in several difficult-to-treat cancers including non-small cell lung cancer but has only shown modest efficacy in small cell lung cancer. We will investigate whether a protein called PPAR-alpha can be a therapeutic target to overcome immunotherapy resistance in small cell lung cancer.  

Freedom From Smoking Clinic
, | Oct 25, 2021
Lung Mind Alliance Convening
, | Dec 08, 2021