University of Illinois College of Medicine at Chicago
Targeting Hexosamine Pathway in an Aggressive Subtype of Lung Cancer
The formation of cancer is regulated by changes to specific genes that control energy and processing of nutrients. These steps are needed for the cancer to keep proliferating. We have found that the cellular content of sugar-related molecules called hexosamines is dramatically increased by a combination of two of the most common gene mutations in lung cancer. This increase leads to important processes that occur in cancer development. We will study how these mutations increase hexosamine metabolism in lung cancer, and evaluate if targeting this molecule can be beneficial for treating lung cancer. This research has the potential to identify new treatment strategies for lung cancer.