UT-Southwestern Medical Center
Lung Cancer Mutations Increase Levels of Polyamines
Polyamines are naturally occurring molecules that are essential for cell growth. They can contribute to tumor growth and survival, but the way in which this occurs is unknown. We have found that polyamine content is dramatically increased by combinations of the three of the most common mutations in lung cancer—P53, KRAS, and LKB1. We will study how these mutations elevate polyamine levels in lung cancer cells. We will then extend these findings to mouse and human lung tumors. Our research has the potential to provide a foundation for novel therapeutic strategies in lung cancer.