Camila Lopes-Ramos, Ph.D.

Institution: Harvard University

Project: Sex and Gender Differences in Lung Adenocarcinoma

Grant(s): Lung Cancer Discovery Award

Lung adenocarcinoma affects men and women differently, including incidence, survival, and treatment response. However, most laboratory and clinical research as well as existing approaches to precision medicine generally ignore the sex of the individual. While previous studies have investigated the effect of single genes, we have come to recognize that genes work together in networks. We have shown that differences between men and women are reflected in gene regulatory networks, creating differences in how genes are connected and activated. We will integrate mutations, and sex-based regulatory networks to better understand gene regulation and the factors that drive the observed sex differences in lung adenocarcinoma. Our innovative approach can provide insights into why some therapies have differential effects in men and women, and new ways to optimize therapeutic responses in each sex, ultimately leading to clinical studies directed toward improving lung cancer treatments. 
 

Freedom From Smoking Clinic
, | May 02, 2022
Freedom From Smoking Clinic
Virginia Beach, VA | May 10, 2022