Bria Coates, MD 

Bria Coates, MD 

Ann & Robert H. Lurie Children's Hospital of Chicago 

Research Project:
Why Does SARS-CoV-2 Rarely Cause Severe Disease in Children?

Grant Awarded:

  • COVID-19 Respiratory Virus Research Award

Research Topic:

  • biomarkers

Research Disease:

  • COVID-19

Unlike other respiratory viruses, the novel coronavirus SARS-CoV-2 causes severe illness and death in the elderly, but only rarely causes severe disease in children. Prior exposure to common cold coronaviruses may result in T cells which can initiate an immune response to SARS-CoV-2. These T cells may not mount a strong response against SARS-CoV-2 and may lead to disrupted antiviral responses. We will study whether children are less likely than adults to have these T cells in the blood and nasal mucosa and hence less likely to develop severe COVID-19. We will examine the age-related differences in the body’s response to SARS-CoV-2. Our research will help define protective responses to SARS-CoV-2, identify biomarkers that predict illness severity, and reveal new therapeutic targets. 

Page last updated: September 22, 2022

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