University of Pennsylvania
How Class of Drugs Decreases Airway Hyperresponsiveness
Histone deacetylase inhibitors are a class of drugs which are being evaluated for use in a variety of diseases. It has been proposed that these drugs decrease airway hyperresponsiveness (over reaction to stimuli), which is a hallmark of asthma. These drugs will be given to mice, some with experimentally-induced asthma, to further improve the understanding of how histone deacetylase decreases airway hyperresponsiveness.