Regents of the University of Minnesota - Twin Cities
Unraveling the Mystery of Drug Resistance in Tuberculosis
Two billion people, including 12 million U.S. residents, are infected with the bacterium that causes tuberculosis, Mycobacterium tuberculosis. Current treatments require a minimum of six months, have adverse side effects and are not fully effective in preventing relapse of disease. Treatment failure is common and has led to the emergence of drug-resistant TB. Surprisingly little is known about the molecular basis for TB drug resistance. We will study critical cellular functions that can be targeted to rapidly kill M. tuberculosis regardless of cell tolerance to existing drugs. These studies will enable the discovery of new drugs to accelerate and increase TB cure rates.