Andrew A Wilson, M.D.

In late 2019, a novel coronavirus strain now known as SARS-CoV-2 emerged in China and has subsequently spread around the globe, sickening millions and killing hundreds of thousands of people with the disease COVID-19. Disease outcomes have been associated with patient factors including fixed attributes such as age and other illnesses like diabetes, hypertension and COPD. Critically, early evidence likewise suggests a link between cigarette smoking and COVID-19 susceptibility and severity. Whether the use of electronic cigarettes might contribute to disease risk remains unknown, but could be critical given its prevalence in the population. Studies to determine whether these common, modifiable behaviors increase COVID-19 risk are urgently needed. We will study a model of SARS-CoV-2 infection in patient-derived lung alveolar epithelial cells to determine whether cigarette smoke or e-cigarette vapor exposure increases associated risk or severity.