University of Tennessee Health Science Center
Identifying New Targets to Treat Acute Lung Injury
Mechanical ventilation and oxygen therapy are common treatment options for acute lung injury (ALI), alt-hough both therapies are known to cause further damage to the lungs. Recent studies suggest that a particu-lar type of ion channel, 2-pore domain potassium (K2P), can sense signals at the cell membrane and convert them into specific cellular functions. The central hypothesis of this proposal is that the K2P channel is regulated by the treatments above and, in turn, regulates the release of inflammatory mediators. Dr. Schwingshackl and team hope to identify these channels as new potential targets for the development of novel treatment strategies against ALI.