Amanda Poholek, Ph.D.

Amanda Poholek, Ph.D.

Institution: University of Pittsburgh

Project: Learning Protein’s Role in Allergic Asthma Could Lead to New Treatments

Grant(s): Innovation Award

Allergic asthma is a chronic lung disease with no cure, with cases rising in adults and children. Inhalation of allergens such as house dust mite leads to allergic inflammation of the lung, yet precisely how allergens drive an immune response in the lung tissue is not clear. We are studying the role of a protein called Blimp-1 in promoting development of an inflammatory cell called Th2, which is inappropriately activated in asthma. This process may be critical to promoting allergic asthma. We will identify the lung-specific environmental factors that promote Blimp-1 dependent Th2 cells in allergic asthma. We expect these studies to identify novel drug targets for therapies for allergic asthma.

Supported by the Mary Fuller Russell Fund

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