Alison Taylor, Ph.D.

Alison Taylor, Ph.D.

Institution: Columbia University

Project: Effect of Changes in Chromosome Number in Lung Squamous Cell Carcinoma

Grant(s): Lung Cancer Discovery Award

Over 90% of tumors have cells without the correct number of chromosomes, termed “aneuploid” cells. Some whole chromosomes or large chromosome fragments may be duplicated or lost. It has been shown that this aneuploidy is a contributing factor in the formation of cancers. We aim to understand the effects of these different changes in chromosome number in lung squamous cell carcinoma. For our studies, we are making use of a new technology that allows us to cut chromosomes at specific locations. By doing this, we are mimicking errors in the segregation of chromosomes that occur in tumor cells. We will then study the effects of these cuts on chromosome number and loss of large chromosome segments. With knowledge of how these chromosomal changes contribute to cancer formation, we will uncover new ways that cells can become cancerous. These findings will be critical for designing new cancer treatments.

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