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Shiladitya Sengupta, Ph.D.

Sengupta
Brigham and Women's Hospital, Inc.
Next Generation Multifunctional Nanotherapy for Targeting Lung Cancer
Lung Cancer Discovery Award

In the search for a cure for lung cancer, several promising approaches have emerged. These include the development of molecularly-targeted treatments that block cancer pathways; the use of immune checkpoint inhibitors to activate the immune system against cancer cells, and the use of nanotechnology to target cancer. Nanotechnology manipulates matter at the molecular level. We will explore a novel treatment that combines all three approaches. We will engineer two next-generation nanoparticles. They can combine a phosphatidylinositol 3 kinase (PI3K) inhibitor a drug that inhibits PI3K enzymes, which are involved in cancer growth, with immune checkpoint inhibitors that activate immune cells against lung cancer. The PI3K can increase the response to the immune checkpoint inhibitors. This approach may result in a significant advance in treatment of lung cancer, which can lead to improved outcomes with reduced side effects.

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