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Piro Lito, M.D., Ph.D.

Headshot of Piro Lito, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
Treating Lung Cancer With KRAS Mutation

Approximately 25 percent of patients with lung cancer harbor mutations in a cancer-causing protein called KRAS. This is the most frequently activated protein found in cancer patients. While precision medicines--which target proteins that are activated less frequently--have revolutionized the care of patients with lung cancer, no such medicines are available to treat patients whose tumors harbor a KRAS mutation. Recent advances have led to the discovery of drugs that target a particular KRAS mutation, KRAS G12C, which is the most common KRAS mutation in patients with lung cancer. Building on our work describing the mechanism of action of these drugs, we will investigate how cancer cells bypass inhibition of KRAS and then identify optimal combination therapies, in order to maximize the effect of these drugs in patients.

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