This website uses cookies. By continuing you are agreeing to our privacy policy.

Karim Bahmed, Ph.D.

Karim Bahmed
Temple University
Mitochondrial Dysfunction in Human Primary Alveolar Type II Cells in Emphysema
Catalyst Award

Emphysema is caused by smoking and secondhand smoking. How emphysema develops is still not well understood. Emphysema is characterized by lung tissue destruction and death of cells in the alveoli (air sacs). Alveolar cells play an important role in lung tissue repair after injury. We have found that emphysema patients exhibit higher DNA damage in mitochondria, the microscopic power plants, inside alveolar cells. This damaged DNA contributes to cell death. We will study the mechanism of mitochondrial DNA damage in alveolar cells to determine whether a protein called XLF, which is involved in mitochondrial DNA damage repair, protects cells against this disease development and can serve as a novel therapeutic target. Targeting XLF can provide a new strategy to repair alveolar cells and slow down the development of emphysema.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl
What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.