This website uses cookies. By continuing you are agreeing to our privacy policy.

Junran Zhang, M.D., Ph.D.

Junran Zhang
The Ohio State University College of Medicine
Interruption of Metabolism and DNA Damage Response in Cancer Therapy
Lung Cancer Discovery Award

Squalene epoxidase (SQLE), an enzyme required for cholesterol synthesis, is frequently overexpressed in NSCLC and is associated with poor patient prognosis. Our recent genome-wide loss-of-function screen and preliminary data suggest that SQLE-inhibited NSCLC cells are sensitive to inhibitors targeting the DNA damage response protein CHK1 and its upstream factor ATR. Our studies will help save the lives of lung cancer patients by identifying novel therapeutic approaches.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl
What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.