Junran Zhang, M.D., Ph.D.
The Ohio State University College of Medicine
Interruption of Metabolism and DNA Damage Response in Cancer Therapy
Lung Cancer Discovery Award
Squalene epoxidase (SQLE), an enzyme required for cholesterol synthesis, is frequently overexpressed in NSCLC and is associated with poor patient prognosis. Our recent genome-wide loss-of-function screen and preliminary data suggest that SQLE-inhibited NSCLC cells are sensitive to inhibitors targeting the DNA damage response protein CHK1 and its upstream factor ATR. Our studies will help save the lives of lung cancer patients by identifying novel therapeutic approaches.
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