Joseph Barbi, Ph.D.
Roswell Park Cancer Institute
Funded by LUNG FORCE
Will Blocking A Nerve Protein Help Stop Lung Tumor Growth?
A major contributing factor to the hard-to-treat nature of lung cancer lies in the ability of tumors to suppress the patient's immune defenses. Among the foremost contributors to this dampening are the so-called "Regulatory T cells" or Tregs, which accumulate in lung tumors and suppress the activity of other immune cells, preventing tumor eradication. A protein called neuritin is highly produced by tumor Tregs and is important for immune suppression. We will explore how neuritin allows Treg accumulation and function in tumors, and we will determine if blocking neuritin can unleash the immune system to halt lung tumor progression.
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