Hong Ji, Ph.D. | American Lung Association

This website uses cookies. By continuing you are agreeing to our privacy policy.

Hong Ji, Ph.D.

Cincinnati Children's Hospital Medical Center - Research Foundation
Funded in partnership with the AAAAI Foundation
Seeking Personalized Treatment for Severe Asthma in Children

Asthma remains the leading cause of emergency care and hospitalization in children. Standard asthma treatments including bronchodilators and corticosteroids and are not completely effective in all asthmatics, especially in those with severe/difficult-to-treat asthma. There remains a great need for alternative personalized asthma therapy. We will address this unmet need by identifying biological mechanisms that switch genes on and off for difficult-to-treat childhood asthma and investigate how they contribute to the diversity of patients' disease and response to treatment. Once completed, this research will facilitate better identification of difficult-to-treat asthma and may provide novel therapeutic targets for personalized asthma therapies.

Update: To date, we have studied genetic variations in 106 asthmatic children, half with easy-to-control asthma, half with difficult-to-control asthma. We have identified variations associated with difficult-to-control asthma, which are located in genes relevant to asthma and response to current asthma treatment. Interestingly, some of these markers are also associated with skin sensitization and antibodies called IgE that are produced by the immune system in reaction to allergens. This finding supports the role of IgE in asthma severity and suggests a link between skin sensitization and asthma severity.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl
What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.