Griffith Parks, Ph.D.
University of Central Florida
Novel Oncolytic Virus for Redirecting NK Cell Killing of Lung Cancer Cells
Lung Cancer Discovery Award
Viruses are now being used as anti-cancer agents. We will design a cancer therapy based on a virus called parainfluenza virus 5, which naturally infects the respiratory tract but is not associated with human disease. Using a mouse model system, we will combine a mutant version of parainfluenza virus which is specific for lung tumor cells and a type of normal human immune cell called Natural Killer (NK) cells, which recognize cancer cells and kill them. Through this combined approach we will harness the immune system's ability to recognize this novel virus to aid in clearance of lung cancer cells.
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